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Ann Nutr Metab. 2010;57(1):40-9. doi: 10.1159/000312666. Epub 2010 Jul 29.

Regular daily intake of black tea improves oxidative stress biomarkers and decreases serum C-reactive protein levels in type 2 diabetic patients.

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1
National Nutrition and Food Technology Research Institute, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. neytra@yahoo.com

Abstract

BACKGROUND:

This study was undertaken to evaluate the possible effects of different daily doses of black tea intake on certain oxidative stress, inflammatory and metabolic biomarkers in patients with type 2 diabetes mellitus (T2DM).

METHODS:

Forty-six patients with known T2DM were randomly assigned either to the test (n = 23, 57.0 +/- 7.9 years) or the control (n = 23, 55.4 +/- 8.3 years) group. Following a one-week 'run-in' period, the test group received 150, 300, 450 and 600 ml of black tea extract (BTE) during the weeks 1, 2, 3 and 4, respectively. The control group received 150 ml BTE a day throughout the intervention period. Dietary, anthropometric and biochemical assessments were performed at the end of each week.

FINDINGS:

Serum total antioxidant capacity was enhanced similarly in both test and control groups. However, daily intake of 2 cups of BTE by the test group showed a suppressing effect on serum malondialdehyde. Serum C-reactive protein significantly decreased and glutathione levels increased following the intake of 4 cups (600 ml) of BTE a day.

CONCLUSION:

Regular intake of BTE had anti-oxidative and anti-inflammatory effects in patients with T2DM. These findings may, to some extent, explain the mechanisms underlying the protective effects of drinking tea against cardiovascular disease.

PMID:
20668372
DOI:
10.1159/000312666
[Indexed for MEDLINE]
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