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Nephrol Dial Transplant. 2010 Nov;25(11):3792-3. doi: 10.1093/ndt/gfq457. Epub 2010 Jul 28.

Tribulus terrestris-induced severe nephrotoxicity in a young healthy male.

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Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.


Herbal medications are being progressively utilized all over the world. Nevertheless, herbal remedies are not without hazards and several cases of adverse reactions have been described. Tribulus terrestris is traditionally used because of its aphrodisiac and antiurolithiatic activities with almost complete inhibition of stone formation. We report a case of T. terrestris-induced hepatotoxicity, nephrotoxicity and neurotoxicity in an Iranian male patient who used the plant's extract to prevent kidney stone formation. He presented with seizure and very high serum aminotransferases and creatinine after consuming herbal water for 2 days. Discontinuation of the herbal remedy resulted in improvement in symptoms and normalization of his liver enzymes.

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