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Head Neck. 2011 Apr;33(4):562-5. doi: 10.1002/hed.21492.

Positron emission tomography and positron emission tomography-CT evaluation for recurrent papillary thyroid carcinoma: meta-analysis and literature review.

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1
Department of Head and Neck Surgery, University of California - Los Angeles, Los Angeles, California, USA.

Abstract

BACKGROUND:

Sensitivity and specificity data regarding positron emission tomography (PET) and PET/CT for surveillance of well-differentiated thyroid cancer does not evaluate subtypes separately. Papillary and follicular thyroid carcinoma may have different characteristics on PET/CT imaging and so should be investigated individually.

METHODS:

This is a systematic meta-analysis of studies using PET for surveillance in patients with papillary thyroid carcinoma.

RESULTS:

Using different statistical models, combined sensitivity of PET and PET/CT for papillary thyroid carcinoma was 77% by the fixed effect model and 82% by the random-effects model, specificity was calculated as 85% and 84%, respectively. Meta-regression was performed to evaluate whether I-131 negativity affected PET positivity; no correlation between I-131 negativity and PET sensitivity or specificity was found.

CONCLUSION:

PET and PET/CT are useful modalities in surveillance of papillary thyroid carcinoma. To our knowledge, this is the first study to examine papillary thyroid carcinoma independently of other subtypes of well-differentiated thyroid carcinoma.

PMID:
20665734
DOI:
10.1002/hed.21492
[Indexed for MEDLINE]
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