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Nanomedicine (Lond). 2010 Jul;5(5):739-54. doi: 10.2217/nnm.10.45.

MRI manifestation of novel superparamagnetic iron oxide nanoparticles in the rat inner ear.

Author information

1
Department of Otolaryngology, University of Tampere, FM1, 3rd Floor, Biokatu 6, 33520 Tampere, Finland. jing.zou@uta.fi

Abstract

AIM:

Superparamagnetic iron oxide nanoparticles hierarchically coated with oleic acid and Pluronic F127 copolymers (POA@SPION) have shown exceptional T2 contrast enhancement. The aim of the present work was to investigate the MRI manifestation of POA@SPION in the inner ear.

MATERIALS & METHODS:

A total of 26 male Wister rats were selected for testing POA@SPION administered through intracochlear, intratympanic and intravenous routes. MRI was performed with a 4.7 T MR scanner.

RESULTS & CONCLUSION:

POA@SPION can be introduced into the perilymph space, after which it becomes widely distributed and can demonstrate the integrity of the perilymph-endolymph barrier. Positive highlighting of the endolymph compartment against the darkened perilymph was visualized for the first time. POA@SPION passed through the middle-inner ear barriers in only small amounts, but stayed in the perilymph for 3 days. They did not traverse the blood-perilymph barrier or blood-endolymph barrier. The inner ear distribution of POA@SPION was confirmed by histology. POA@SPION is a promising T2 negative contrast agent.

PMID:
20662645
DOI:
10.2217/nnm.10.45
[Indexed for MEDLINE]

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