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Antimicrob Agents Chemother. 2010 Oct;54(10):4503-5. doi: 10.1128/AAC.01707-09. Epub 2010 Jul 26.

Colistin dosing and nephrotoxicity in a large community teaching hospital.

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  • 1Department of Pharmacy, Orlando Health, Orlando, Florida, USA. andrew.deryke@orlandohealth.com

Abstract

Thirty adult patients who received intravenous colistin (5.1 ± 2.4 mg/kg/day) were reviewed to evaluate dosing with respect to nephrotoxicity, which occurred in 10 (33%) patients within the first 5 days of treatment. Excessive colistin dosing was frequent (47%), often (71%) resulted from the use of actual body weight in obese patients, and was associated with higher rates of nephrotoxicity (80% versus 30%, P = 0.019).

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