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Biochem Soc Trans. 2010 Aug;38(4):1144-9. doi: 10.1042/BST0381144.

What are natural antisense transcripts good for?

Author information

1
RNA Biology Group, Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. andreas.werner@ncl.ac.uk

Abstract

NATs (natural antisense transcripts) are important regulators of eukaryotic gene expression. Interference between the expression of protein-coding sense transcripts and the corresponding NAT is well documented. In the present review, we focus on an additional, higher-order role of NATs that is currently emerging. The recent discovery of endogenous siRNAs (short interfering RNAs), as well as NAT-induced transcriptional gene silencing, are key to the proposed novel function of NATs.

PMID:
20659019
PMCID:
PMC4284956
DOI:
10.1042/BST0381144
[Indexed for MEDLINE]
Free PMC Article

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