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Nat Struct Mol Biol. 2010 Aug;17(8):948-54. doi: 10.1038/nsmb.1877. Epub 2010 Jul 25.

The A-repeat links ASF/SF2-dependent Xist RNA processing with random choice during X inactivation.

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1
Department of Biochemistry and Biophysics, University of California, San Francisco, California, USA.

Abstract

One X chromosome, selected at random, is silenced in each female mammalian cell. Xist encodes a noncoding RNA that influences the probability that the cis-linked X chromosome will be silenced. We found that the A-repeat, a highly conserved element within Xist, is required for the accumulation of spliced Xist RNA. In addition, the A-repeat is necessary for X-inactivation to occur randomly. In combination, our data suggest that normal Xist RNA processing is important in the regulation of random X-inactivation. We propose that modulation of Xist RNA processing may be part of the stochastic process that determines which X chromosome will be inactivated.

PMID:
20657585
PMCID:
PMC4336797
DOI:
10.1038/nsmb.1877
[Indexed for MEDLINE]
Free PMC Article
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