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Molecules. 2010 May 25;15(5):3757-74. doi: 10.3390/molecules15053757.

Photochemical transformations of tetrazole derivatives: applications in organic synthesis.

Author information

1
CQFM - Centro de Química-Física Molecular, IN - Institute of Nanoscience and Nanotechnology, Departamento de Engenharia Química e Biológica, Instituto Superior Técnico, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal. luisfrija@ist.utl.pt

Abstract

Tetrazoles remain a challenge to photochemists. Photolysis leads to cleavage of the tetrazolyl ring, may involve various photodegradation pathways and may produce a diversity of photoproducts, depending on the structure and conformational flexibility of the substituents and the possibility of tautomerism. If the photochemistry of tetrazoles is considered within the frame of synthetic applications the subject is even more challenging, since the ultimate goal is to achieve selectivity and high yield. In addition, the photoproducts must remain stable and allow isolation or trapping, in order to be used in other reactions. This review summarises the photochemical transformations of tetrazole derivatives that can be used as effective synthetic routes to other compounds.

PMID:
20657512
PMCID:
PMC6257500
DOI:
10.3390/molecules15053757
[Indexed for MEDLINE]
Free PMC Article

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