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Crit Care Med. 2010 Oct;38(10):2043-51. doi: 10.1097/CCM.0b013e3181ef44dc.

Premarin improves outcomes of spinal cord injury in male rats through stimulating both angiogenesis and neurogenesis.

Author information

1
Department of Obstetrics and Gynecology, Chi Mei Medical Center, Tainan, Taiwan. 891201@mail.chimei.org.tw

Abstract

OBJECTIVE:

To ascertain whether Premarin improves spinal cord injury outcomes in male rats by stimulating both angiogenesis and neurogenesis.

DESIGN:

Chi Mei Medical Center research laboratory.

SUBJECTS:

Male Sprague-Dawley rats 240-258 g.

INTERVENTIONS:

Anesthetized rats, after the onset of spinal cord injury, were divided into two groups and given the vehicle solution (1 mL/kg of body weight) or Premarin (1 mg/kg of body weight). Saline or Premarin solutions were administered intravenously and immediately after spinal cord injury.

MEASUREMENTS AND MAIN RESULTS:

Premarin (an estrogen sulfate) causes attenuation of spinal cord injury-induced spinal cord infarction and hind limb locomotor dysfunction. Spinal cord injury-induced apoptosis as well as activated inflammation was also significantly Premarin-reduced. In injured spinal cord, angiogenesis, neurogenesis, and production of an antiinflammatory cytokine were all Premarin therapy-promoted.

CONCLUSIONS:

Our results indicate that Premarin therapy may protect against spinal cord apoptosis after spinal cord injury through mechanisms stimulating both angiogenesis and neurogenesis in male rats.

Comment in

PMID:
20657272
DOI:
10.1097/CCM.0b013e3181ef44dc
[Indexed for MEDLINE]
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