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Cell. 2010 Jul 23;142(2):200-2. doi: 10.1016/j.cell.2010.07.007.

Calcium and energy: making the cake and eating it too?

Author information

1
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 92105, USA. douglas.green@stjude.org

Abstract

Mitochondrial calcium ions promote a number of events that sustain ATP levels in the cell. Cardenas et al. (2010) now demonstrate that the inositol 1,4,5-triphosphate receptor at the endoplasmic reticulum constitutively provides calcium for mitochondria. In the absence of this calcium transfer, cells use autophagy to sustain survival.

PMID:
20655464
DOI:
10.1016/j.cell.2010.07.007
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