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Cell. 2010 Jul 23;142(2):198-200. doi: 10.1016/j.cell.2010.07.001.

No bones about it: insulin modulates skeletal remodeling.

Author information

1
Maine Medical Center Research Institute, Scarborough, ME 04074, USA. rosenc@mmc.org

Abstract

Advancing the hypothesis that bone remodeling is intimately linked to metabolic homeostasis, Fulzele et al. (2010) and Ferron et al. (2010) present evidence that insulin signaling promotes the activation of bone-forming osteoblasts and enhances production of osteocalcin, a secreted mediator of insulin sensitivity, through modulation of bone resorption.

PMID:
20655463
DOI:
10.1016/j.cell.2010.07.001
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