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J Cardiothorac Vasc Anesth. 2010 Dec;24(6):939-45. doi: 10.1053/j.jvca.2010.05.008. Epub 2010 Jul 22.

Brain natriuretic peptide (BNP) as a biomarker of myocardial ischemia-reperfusion injury in cardiac transplantation.

Author information

1
Department of Anesthesiology, Columbia-Presbyterian Medical Center, New York, NY 10032, USA. dm2655@columbia.edu

Abstract

OBJECTIVES:

To evaluate brain natriuretic peptide (BNP) as a biomarker of ischemia-reperfusion injury in cardiac transplantation

DESIGN:

A prospective cohort study.

SETTING:

A single academic medical center.

PARTICIPANTS:

Adult patients undergoing orthotopic cardiac transplantation (n = 25).

INTERVENTIONS:

None.

MEASUREMENTS AND MAIN RESULTS:

The authors performed serial measurements of BNP and troponin-I in cardiac allograft donors and recipients, determining the relationship between these biomarkers and established risk factors for and measures of early graft dysfunction. Postoperative BNP correlated moderately with allograft ischemic time (ρ = 0.52, p = 0.01), donor BNP (ρ = 0.45, p = 0.03), and donor troponin-I (ρ = 0.49, p = 0.01). Postoperative BNP was higher in patients with persistently elevated inotrope requirements and enabled the early identification of such patients. In contrast, there was no association between postoperative troponin-I and these same parameters.

CONCLUSIONS:

Postoperative BNP is associated with preimplantation and clinical performance parameters related to allograft ischemia-reperfusion injury at the time of cardiac transplantation, providing preliminary evidence to support its potential use as an ischemia-reperfusion injury biomarker in this context.

PMID:
20655247
DOI:
10.1053/j.jvca.2010.05.008
[Indexed for MEDLINE]

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