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Cell. 1991 Jun 28;65(7):1153-63.

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene.

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1
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.

Abstract

The c-abl proto-oncogene, which encodes a cytoplasmic protein-tyrosine kinase, is expressed throughout murine gestation and ubiquitously in adult mouse tissues. However, its levels are highest in thymus, spleen, and testes. To examine the in vivo role of c-abl, the gene was disrupted in embryonic stem cells, and the resulting genetically modified cells were used to establish a mouse strain carrying the mutation. Most mice homozygous for the c-abl mutation became runted and died 1 to 2 weeks after birth. In addition, many showed thymic and splenic atrophy and a T and B cell lymphopenia.

PMID:
2065352
[Indexed for MEDLINE]

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