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Mol Cell Biochem. 2010 Nov;344(1-2):211-5. doi: 10.1007/s11010-010-0544-0. Epub 2010 Jul 22.

Regulation of GSK3 isoforms by phosphatases PP1 and PP2A.

Author information

1
Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.

Abstract

Dephosphorylation of phospho GSK3 isoforms, from COS-7 cells, was determined in vitro and in cultured cells in the absence or the presence of okadaic acid and lithium. Our results indicate a preferential dephosphorylation of phospho GSK3α by PP2A phosphatase, whereas dephosphorylation of phospho GSK3β mainly takes place by PP1 phosphatase.

PMID:
20652371
DOI:
10.1007/s11010-010-0544-0
[Indexed for MEDLINE]

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