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J Neurol. 2010 Dec;257(12):2059-64. doi: 10.1007/s00415-010-5660-y. Epub 2010 Jul 22.

Functional outcome and quality of life 5 and 12.5 years after aneurysmal subarachnoid haemorrhage.

Author information

1
Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, Heidelberglaan 100, 3484 CX, Utrecht, The Netherlands. p.greebe@umcutrecht.nl

Abstract

Patients who recover from aneurysmal subarachnoid haemorrhage (SAH) often remain disabled or have persisting symptoms with a reduced quality of life (QoL). We assessed functional outcome and QoL 5 and 12.5 years after SAH. In a consecutive series of 64 patients with mean age at SAH of 51 years, initial outcome assessments had been performed at 4 and 18 months after SAH. At the initial and current outcome assessments, functional outcome was measured with the modified Rankin Scale (mRS) and QoL with the SF-36 and a visual analogue scale (VAS). We studied the change in outcome measurements over time. We used the non-parametric Wilcoxon test to compare differences in mRS grades and calculated differences with corresponding 95% confidence intervals in the domain scores of the SF-36 and the VAS. After 5 years, seven patients had died and five patients had missing data. Compared with the 4-month follow-up, the mRS had improved in 29 of the 52 patients, remained similar in 19 patients. The overall QoL (SF-36 domains and VAS score) was better. At 12.5 years an additional six patients had died. Compared to the 4-month study, 25 of the 46 remaining patients had improved mRS, 12 had remained the same and in nine patients the mRS had worsened. Between the 5 and the 12.5 years follow-up, the improvement in mRS had decreased but patients reported overall a better QoL. Among long-time survivors, QoL may improve more than a decade after SAH.

PMID:
20652302
PMCID:
PMC2999856
DOI:
10.1007/s00415-010-5660-y
[Indexed for MEDLINE]
Free PMC Article

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