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Arch Gynecol Obstet. 2011 Feb;283(2):255-60. doi: 10.1007/s00404-010-1588-9. Epub 2010 Jul 21.

Effect of cesarean section on the risk of perinatal transmission of hepatitis C virus from HCV-RNA+/HIV- mothers: a meta-analysis.

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1
Research Center for Gastroenterology and Liver Disease, University of Medical Sciences, Tehran, Iran.

Abstract

BACKGROUND:

Hepatitis C virus (HCV) vertical transmission is considered the main route of HCV infection in children. Some authors have stated that cesarean section (C/S) can reduce perinatal HCV transmission. However, the study findings are heterogeneous and high-quality studies are lacking.

AIMS:

To evaluate the effect of mode of delivery on the risk of perinatal mother-to-infant transmission of HCV.

METHODS:

Only the peer-reviewed published studies that compared perinatal transmission rate of HCV in elective or emergency cesarean section with vaginal delivery in HCV-RNA+/HIV- mothers were included. We applied the random effect model of DerSimonian and Laird method with heterogeneity and sensitivity analyses.

RESULTS:

We identified 8 studies that involved 641 unique mother-infant pairs which fulfilled our inclusion criteria. Aggregation of study results did not show a significant decrease in HCV vertical transmission among study (mothers who underwent C/S) versus control (mothers who gave birth vaginally) patients [pooled odds ratio, 1.1 (95% CI 0.45-2.67)]. The P value was 0.35 for our test of heterogeneity.

CONCLUSIONS:

Our meta-analysis suggests that C/S does not decrease perinatal HCV transmission from HCV-RNA+/HIV- mothers to infants.

PMID:
20652289
DOI:
10.1007/s00404-010-1588-9
[Indexed for MEDLINE]
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