Format

Send to

Choose Destination
Cytokine. 2010 Oct-Nov;52(1-2):102-7. doi: 10.1016/j.cyto.2010.06.011. Epub 2010 Jul 22.

Interleukin-12 as an adjuvant for induction of protective antibody responses.

Author information

1
Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA. metzged@mail.amc.edu

Abstract

Interleukin (IL)-12 is a pivotal cytokine that strongly stimulates Th1-associated cellular immunity. It is now recognized that IL-12 also activates humoral immunity to both T-dependent and T-independent antigens. This has let to considerable interest in exploiting IL-12 as a vaccine adjuvant for protection against various bacterial and viral pathogens, particularly in the lung. Studies examining the efficacy of IL-12-mediated effects on protective antibody response in the mouse model are summarized in this review.

PMID:
20650650
PMCID:
PMC2935143
DOI:
10.1016/j.cyto.2010.06.011
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center