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J Steroid Biochem Mol Biol. 1991 Jun;38(6):717-20.

Morphological effects of the catechol estrogens on rat epididymal epithelia.

Author information

1
Department of Physiology, Faculty of Medicine, University of Pretoria, South Africa.

Abstract

The 2-hydroxy and 4-hydroxyestradiols (2-/4-OHE2) caused marked cytotoxic effects, including vacuolation and nuclear changes, in rat epididymal epithelia, after exposure to very low levels (40 ng/rat/week) for 20 weeks. The effects of the 2-/4-OHE2 metabolites were more pronounced than that of estradiol-17 beta (E2).

PMID:
2064987
DOI:
10.1016/0960-0760(91)90083-h
[Indexed for MEDLINE]

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