Send to

Choose Destination
Ann N Y Acad Sci. 2010 Jul;1201:96-103. doi: 10.1111/j.1749-6632.2010.05627.x.

Animal and human studies with the mitochondria-targeted antioxidant MitoQ.

Author information

Department of Chemistry, University of Otago, Dunedin, New Zealand.


As mitochondrial oxidative damage contributes to a wide range of human diseases, antioxidants designed to be accumulated by mitochondria in vivo have been developed. The most extensively studied of these mitochondria-targeted antioxidants is MitoQ, which contains the antioxidant quinone moiety covalently attached to a lipophilic triphenylphosphonium cation. MitoQ has now been used in a range of in vivo studies in rats and mice and in two phase II human trials. Here, we review what has been learned from these animal and human studies with MitoQ.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center