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Clin Infect Dis. 2010 Sep 1;51(5):571-4. doi: 10.1086/655697.

The decline of pneumococcal resistance after cessation of mass antibiotic distributions for trachoma.

Author information

1
FI Proctor Foundation, Department of Ophthalmology, University of California, San Francisco, California 94143-0944, USA.

Abstract

After 6 biannual mass distributions of oral azithromycin for trachoma in Ethiopian communities, 76.8% (95% confidence interval [CI], 66.3%-85.1%) of nasopharyngeal Streptococcus pneumoniae isolates from children aged 1-5 years were resistant to macrolides. Twelve and 24 months after the last azithromycin treatment, resistance decreased to 30.6% (95% CI, 18.8%-40.4%; P <.001 ) and 20.8% (95% CI, 12.7%-30.7%; P < .001), respectively. Macrolide resistance decreases after antibiotic pressure is removed.

PMID:
20649409
DOI:
10.1086/655697
[Indexed for MEDLINE]

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