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Epigenetics. 2010 Oct 1;5(7):569-72. Epub 2010 Oct 1.

Human non-CG methylation: are human stem cells plant-like?

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1
Pushchino Branch, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Russia.

Abstract

Non-CG methylation is well characterized in plants, where it appears to play a role in gene silencing and genomic imprinting. Although strong evidence for the presence of non-CG methylation in animals has been available for some time, both its origin and function remain elusive. In this review we discuss available evidence on non-CG methylation in animals in light of evidence suggesting that the human stem cell methylome contains significant levels of methylation outside the CG site.

PMID:
20647766
PMCID:
PMC3037444
[Indexed for MEDLINE]
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