Format

Send to

Choose Destination
See comment in PubMed Commons below
Early Hum Dev. 2010 Jul;86(7):425-32. doi: 10.1016/j.earlhumdev.2010.05.021. Epub 2010 Jun 20.

Estimating the relative contributions of maternal genetic, paternal genetic and intrauterine factors to offspring birth weight and head circumference.

Author information

1
University College London, United Kingdom. f.rice@ucl.ac.uk

Abstract

BACKGROUND:

Genetic factors and the prenatal environment contribute to birth weight. However, very few types of study design can disentangle their relative contribution.

AIMS:

To examine maternal genetic and intrauterine contributions to offspring birth weight and head circumference. To compare the contribution of maternal and paternal genetic effects.

STUDY DESIGN:

Mothers and fathers were either genetically related or unrelated to their offspring who had been conceived by in vitro fertilization.

SUBJECTS:

423 singleton full term offspring, of whom 262 were conceived via homologous IVF (both parents related), 66 via sperm donation (mother only related) and 95 via egg donation (father only related).

MEASURES:

Maternal weight at antenatal booking, current weight and maternal height. Paternal current weight and height were all predictors. Infant birth weight and head circumference were outcomes.

RESULTS:

Genetic relatedness was the main contributing factor between measures of parental weight and offspring birth weight as correlations were only significant when the parent was related to the child. However, there was a contribution of the intrauterine environment to the association between maternal height and both infant birth weight and infant head circumference as these were significant even when mothers were unrelated to their child.

CONCLUSIONS:

Both maternal and paternal genes made contributions to infant birth weight. Maternal height appeared to index a contribution of the intrauterine environment to infant growth and gestational age. Results suggested a possible biological interaction between the intrauterine environment and maternal inherited characteristics which suppresses the influence of paternal genes.

PMID:
20646882
PMCID:
PMC2954294
DOI:
10.1016/j.earlhumdev.2010.05.021
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center