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Dermatitis. 2010 Jul-Aug;21(4):203-6.

Pattern of corticosteroid allergy in Thailand.

Author information

1
Section of Contact Dermatitis, Division of Dermatology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 10400. rapwn@mahidol.ac.th

Abstract

BACKGROUND:

Corticosteroid allergy is a complication of topical therapy detected by patch-testing with corticosteroid allergens.

OBJECTIVE AND METHODS:

Ten-year retrospective review to study the prevalence and patterns of corticosteroid allergy in Thai patients.

RESULTS:

Of 882 patients who were patch-tested, 29 (3.29%) had allergic reactions to corticosteroids. Of these 29 patients, 17 (58.62%) had positive reactions to one corticosteroid, and 12 (41.38%) reacted to multiple corticosteroids. Rates of reaction to corticosteroid groups ranged from 31.03 to 80.95%. Concomitant reactions between groups were noted. The prevalence of topical corticosteroid allergy (using two screening allergens, tixocortol pivalate and budesonide) was 2.27% (20 of 882). Testing with additional steroid allergens in suspected cases increased the prevalence to 3.29%. Tixocortol pivalate detected 51.72% of corticosteroid-allergic cases, and budesonide detected 24.14%. Combining both tixocortol and budesonide detected 68.97% of cases.

CONCLUSION:

Corticosteroid allergy is found to multiple corticosteroids, and concomitant reactions occur across groups. Group D1 corticosteroid esters produced a higher positive reaction rate (61.9%) than groups D2 (52.38%) and A (51.72%). This may be due to different prescribing habits or the easy access to D1 corticosteroids sold over the counter by pharmacies in Thailand.

PMID:
20646671
[Indexed for MEDLINE]

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