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Nat Immunol. 2010 Aug;11(8):674-80. doi: 10.1038/ni.1899. Epub 2010 Jul 20.

Effector T cell plasticity: flexibility in the face of changing circumstances.

Author information

1
Howard Hughes Medical Institute, Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA. kmurphy@pathology.wustl.edu

Abstract

As more states of CD4 T cell differentiation are uncovered, their flexibility is also beginning to be recognized. Components that control the plasticity of CD4 T cell populations include cellular conditions, clonality, transcriptional circuitry and chromatin modifications. Appearance of cellular flexibility may arise from truly flexible genetic programs or, alternatively, from heterogeneous populations. New tools will be needed to define the rules that allow or prohibit cellular transitions.

PMID:
20644573
PMCID:
PMC3249647
DOI:
10.1038/ni.1899
[Indexed for MEDLINE]
Free PMC Article

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