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Arch Dermatol. 1991 Jul;127(7):1023-8.

Successful use of topical vitamin E solution in the treatment of nail changes in yellow nail syndrome.

Author information

1
Department of Dermatology, King's College Hospital, Denmark Hill, London, England.

Abstract

A double-blind controlled study was performed on a patient with long-standing yellow nail syndrome to investigate the potential beneficial role of topical vitamin E solution for the nail changes seen in this disorder. Three nails received active solution containing DL-alpha-tocopherol in dimethyl sulfoxide; three nails received dimethyl sulfoxide only; and the remainder were untreated. After 6 months of therapy, the three nails treated with active solution showed marked clinical improvement and a corresponding increase in nail growth rates. Dimethyl sulfoxide alone produced a small increase in nail growth rate and slight clinical improvement. Active solution was then applied to all of the nails for a further 6 months, resulting in clinical improvement and increased nail growth rates in the remaining nails. These beneficial effects require further study.

PMID:
2064401
[Indexed for MEDLINE]

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