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Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13614-9. doi: 10.1073/pnas.1003600107. Epub 2010 Jul 19.

Osteoinductive ceramics as a synthetic alternative to autologous bone grafting.

Author information

1
Progentix Orthobiology BV, Professor Bronkhorstlaan 10-D, 3723 MB Bilthoven, The Netherlands.

Abstract

Biomaterials can be endowed with biologically instructive properties by changing basic parameters such as elasticity and surface texture. However, translation from in vitro proof of concept to clinical application is largely missing. Porous calcium phosphate ceramics are used to treat small bone defects but in general do not induce stem cell differentiation, which is essential for regenerating large bone defects. Here, we prepared calcium phosphate ceramics with varying physicochemical and structural characteristics. Microporosity correlated to their propensity to stimulate osteogenic differentiation of stem cells in vitro and bone induction in vivo. Implantation in a large bone defect in sheep unequivocally demonstrated that osteoinductive ceramics are equally efficient in bone repair as autologous bone grafts. Our results provide proof of concept for the clinical application of "smart" biomaterials.

PMID:
20643969
PMCID:
PMC2922269
DOI:
10.1073/pnas.1003600107
[Indexed for MEDLINE]
Free PMC Article

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