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Biophys J. 2010 Jul 21;99(2):595-9. doi: 10.1016/j.bpj.2010.04.040.

Electric field-driven disruption of a native beta-sheet protein conformation and generation of a helix-structure.

Author information

1
Theoretische Physik, Universität Kassel, Fachbereich 10, Kassel, Germany. pojeda@physik.uni-kassel.de

Abstract

We demonstrate that an external constant electric field is able to modify the secondary structure of a protein and induce a transition from a beta-sheet into a helix-like conformation. This dramatic change is driven by a global rearrangement of the dipole moments at the amide planes. We also predict electric-field-induced modifications of the intermediate states of the protein.

PMID:
20643079
PMCID:
PMC2905109
DOI:
10.1016/j.bpj.2010.04.040
[Indexed for MEDLINE]
Free PMC Article
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