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Drug Metab Lett. 2010 Aug;4(3):180-4.

Morphologic characterization of PhoenixBio (uPA+/+/SCID) humanized liver chimeric mouse model.

Author information

1
Safety Assessment, GlaxoSmithKline, Research Triangle Park, NC 27709, USA. richard.a.peterson@gsk.com

Abstract

Morphological evaluation of humanized chimeric mouse livers from the PhoenixBio (uPA(+/+)/SCID) mouse model show robust replacement and expansion with human hepatocytes, however areas of human hepatocytes had prominent steatosis and a variable lack of sinusoids which was consistent with decreased hepatocellular perfusion and lacked bile canalicular formation between human and mouse hepatocytes.

PMID:
20642451
[Indexed for MEDLINE]

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