Send to

Choose Destination
Drug Metab Lett. 2010 Aug;4(3):180-4.

Morphologic characterization of PhoenixBio (uPA+/+/SCID) humanized liver chimeric mouse model.

Author information

Safety Assessment, GlaxoSmithKline, Research Triangle Park, NC 27709, USA.


Morphological evaluation of humanized chimeric mouse livers from the PhoenixBio (uPA(+/+)/SCID) mouse model show robust replacement and expansion with human hepatocytes, however areas of human hepatocytes had prominent steatosis and a variable lack of sinusoids which was consistent with decreased hepatocellular perfusion and lacked bile canalicular formation between human and mouse hepatocytes.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Bentham Science Publishers Ltd.
Loading ...
Support Center