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Nat Struct Mol Biol. 2010 Aug;17(8):1024-6. doi: 10.1038/nsmb.1875. Epub 2010 Jul 18.

A direct role for Hsp90 in pre-RISC formation in Drosophila.

Author information

1
Keio University School of Medicine, Tokyo, Japan.

Erratum in

  • Nat Struct Mol Biol. 2011 Apr;18(4):516.

Abstract

Heat-shock proteins (Hsps) are molecular chaperones that control protein folding and function. Argonaute 2 (Ago2), the effector in RNA interference (RNAi), is associated with Hsp90; however, its function in RNAi remains elusive. Here we show that Hsp90 is required for Ago2 to receive the small interfering RNA (siRNA) duplex from the RNA-induced silencing complex-loading complex in RNAi, suggesting a model where Hsp90 modifies Ago2 conformation to accommodate the siRNA duplex.

PMID:
20639883
DOI:
10.1038/nsmb.1875
[Indexed for MEDLINE]

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