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Bioinformatics. 2010 Sep 1;26(17):2204-7. doi: 10.1093/bioinformatics/btq351. Epub 2010 Jul 17.

BigWig and BigBed: enabling browsing of large distributed datasets.

Author information

1
Center for Biomolecular Science and Engineering, School of Engineering, University of California, Santa Cruz (UCSC), Santa Cruz, CA 95064, USA.

Abstract

SUMMARY:

BigWig and BigBed files are compressed binary indexed files containing data at several resolutions that allow the high-performance display of next-generation sequencing experiment results in the UCSC Genome Browser. The visualization is implemented using a multi-layered software approach that takes advantage of specific capabilities of web-based protocols and Linux and UNIX operating systems files, R trees and various indexing and compression tricks. As a result, only the data needed to support the current browser view is transmitted rather than the entire file, enabling fast remote access to large distributed data sets.

AVAILABILITY AND IMPLEMENTATION:

Binaries for the BigWig and BigBed creation and parsing utilities may be downloaded at http://hgdownload.cse.ucsc.edu/admin/exe/linux.x86_64/. Source code for the creation and visualization software is freely available for non-commercial use at http://hgdownload.cse.ucsc.edu/admin/jksrc.zip, implemented in C and supported on Linux. The UCSC Genome Browser is available at http://genome.ucsc.edu.

PMID:
20639541
PMCID:
PMC2922891
DOI:
10.1093/bioinformatics/btq351
[Indexed for MEDLINE]
Free PMC Article

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