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Cardiovasc Res. 2010 Nov 1;88(2):229-40. doi: 10.1093/cvr/cvq239. Epub 2010 Jul 16.

Mitochondria in the diabetic heart.

Author information

1
Department of Cardiology, University of Freiburg, Freiburg, Germany.

Abstract

Diabetes mellitus increases the risk of developing cardiovascular diseases such as coronary artery disease and heart failure. Studies have shown that the heart failure risk is increased in diabetic patients even after adjusting for coronary artery disease and hypertension. Although the cause of this increased heart failure risk is multifactorial, increasing evidence suggests that derangements in cardiac energy metabolism play an important role. In particular, abnormalities in cardiomyocyte mitochondrial energetics appear to contribute substantially to the development of cardiac dysfunction in diabetes. This review will summarize these abnormalities in mitochondrial function and discuss potential underlying mechanisms.

PMID:
20639213
PMCID:
PMC2952534
DOI:
10.1093/cvr/cvq239
[Indexed for MEDLINE]
Free PMC Article

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