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Trends Parasitol. 2010 Nov;26(11):517-23. doi: 10.1016/j.pt.2010.06.014. Epub 2010 Jul 17.

Artemisinins and the biological basis for the PfATP6/SERCA hypothesis.

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  • 1Centre for Infection, Cellular and Molecular Medicine, St. George's University of London, Cranmer Terrace, London, UK, SW17 0RE. s.krishna@sgul.ac.uk

Abstract

With the advent of artemisinin resistance, it is timely to revisit the biological basis for the controversial suggestion that this class of antimalarial exerts its activity by inhibiting a calcium ATPase (PfATP6) that is most similar to sarcoplasmic endoplasmic reticulum calcium ATPases (SERCAs). Herein, evidence is discussed that relates to this hypothesis as alternative suggestions for how artemisinins might act have been reviewed elsewhere.

PMID:
20638904
DOI:
10.1016/j.pt.2010.06.014
[PubMed - indexed for MEDLINE]
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