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Cell Host Microbe. 2010 Jul 22;8(1):77-85. doi: 10.1016/j.chom.2010.06.010.

Cytoplasmic viral replication complexes.

Author information

1
Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706, USA.

Abstract

Many viruses that replicate in the cytoplasm compartmentalize their genome replication and transcription in organelle-like structures that enhance replication efficiency and protection from host defenses. In particular, recent studies with diverse positive-strand RNA viruses have further elucidated the ultrastructure of membrane-bound RNA replication complexes and how these complexes function in close coordination with virion assembly and budding. The structure, function, and assembly of some positive-strand RNA virus replication complexes have parallels and potential evolutionary links with the replicative cores of double-strand RNA virus and retrovirus virions and more general similarities with the replication factories of cytoplasmic DNA viruses.

PMID:
20638644
PMCID:
PMC2921950
DOI:
10.1016/j.chom.2010.06.010
[Indexed for MEDLINE]
Free PMC Article

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