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Biosens Bioelectron. 2010 Dec 15;26(4):1152-63. doi: 10.1016/j.bios.2010.06.031. Epub 2010 Jun 25.

How to design magneto-based total analysis systems for biomedical applications.

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Department of Physics, Thin Films and Physics of Nanostructures, Bielefeld University, PB 100131, 33501 Bielefeld, Germany.


This article reviews recent developments on magnetoresistive detection of magnetic beads or nanoparticles by nanoscale sized sensors. Sensors are analyzed from an experimental and a numerical point of view in respect to their capability to either localize the position of a single magnetic particle or to detect the number of particles in a certain range. Guidelines are shown up on how to extend single sensors to sensor arrays with very high spatial resolution and how to modify the sensor shape in order to provide long distance measurements. Further, sensors in biological lab-on-a-chip environments are discussed. The magnetic ratchet and a gravitation based microfluidic component are reviewed as important tools to position and, therefore, detect biological components in continuous-flow devices.

[Indexed for MEDLINE]

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