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Blood Rev. 2010 Jul-Sep;24(4-5):163-9. doi: 10.1016/j.blre.2010.06.002. Epub 2010 Jul 15.

Understanding the genetic regulation of IgE production.

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John Curtin School of Medical Research, Australian National University, Canberra 0200, Australia.


Immunoglobulin E (IgE) is a key mediator of anti-parasitic and anti-tumour immunity. However it is also a critical component of atopic and autoimmune diseases, and elevated serum IgE levels are a common indicator of immune dysregulation. In this review we survey the literature on genetic associations of elevated IgE in humans and mice. We find that defects in a limited number of pathways explain the majority of gene associations with IgE. Commonly, elevated IgE is associated with defects in Th bias and B cell class switching, severe T cell tolerance defects and defects in immunity at the host-environment interface. These genetic data demonstrate the mechanisms of control over IgE production and the manner in which they can be circumvented.

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