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Scand Cardiovasc J. 2010 Aug;44(4):197-200. doi: 10.3109/14017431003624123.

HypoCol (red yeast rice) lowers plasma cholesterol - a randomized placebo controlled study.

Author information

1
Lipid Clinic, Rikshospitalet, Oslo University Hospital, Oslo, Norway. martin.proven.bogsrud@rikshospitalet.no

Abstract

OBJECTIVE:

The primary endpoint in our study was to investigate the effect of a red yeast rice (RYR) product on plasma lipids.

DESIGN:

A randomized, double-blind, placebo controlled study was performed. Patients were randomized to either RYR (HypoCol, 4 capsules/day) (n=22) or placebo (n=20) for 16 weeks. Inclusion criteria were male or female, 18-75 years, LDL-cholesterol between 3.0 and 6.0 mmol/L, fasting triglyceride level less than 4.5 mmol/L.

RESULTS:

Patients receiving RYR experienced a significant reduction in LDL-cholesterol (23.0%) and total cholesterol (15.5%) compared to placebo after 16 weeks of treatment (p<0.001).

CONCLUSION:

The tested red yeast rice product demonstrated a significant cholesterol lowering effect compared to placebo, and was well tolerated in this Caucasian population.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00114855.

PMID:
20636227
DOI:
10.3109/14017431003624123
[Indexed for MEDLINE]

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