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Immunotherapy. 2010 May;2(3):399-418. doi: 10.2217/imt.10.20.

Immunotherapy following hematopoietic stem cell transplantation: potential for synergistic effects.

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1
Department of Microbiology & Immunology, University of Nevada, Reno, NV, USA.

Abstract

Hematopoietic stem cell transplantation (HSCT) is a particularly important treatment for hematologic malignancies. Unfortunately, following allogeneic HSCT, graft-versus-host disease, immunosuppression and susceptibility to opportunistic infections remain among the most substantial problems restricting the efficacy and use of this procedure, particularly for cancer. Adoptive immunotherapy and/or manipulation of the graft offer ways to attack residual cancer as well as other transplant-related complications. Recent exciting discoveries have demonstrated that HSCT could be expanded to solid tissue cancers with profound effects on the effectiveness of adoptive immunotherapy. This review will provide a background regarding HSCT, discuss the complications that make it such a complex treatment procedure following up with current immunotherapeutic strategies and discuss emerging approaches in applying immunotherapy in HSCT for cancer.

PMID:
20635904
PMCID:
PMC3492055
DOI:
10.2217/imt.10.20
[Indexed for MEDLINE]
Free PMC Article
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