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J Hosp Med. 2011 Mar;6(3):151-5. doi: 10.1002/jhm.777.

A descriptive case series of patients with end-stage liver disease hospitalized with variceal bleeding who received pharmacologic venous thromboembolism prophylaxis.

Author information

1
Division of General Internal Medicine, Department of Medicine, Harborview Medical Center, Seattle, Washington 98104, USA. schleyer@u.washington.edu

Abstract

BACKGROUND:

It is unknown whether venous thromboembolism prophylaxis (VTEP) should be utilized in hospitalized patients with end-stage liver disease (ESLD), particularly in those admitted with variceal bleeding.

OBJECTIVE:

We sought to describe a cohort of patients who received pharmacologic VTEP, specifically identifying the occurrence of rebleeding.

DESIGN:

Descriptive case series.

SETTING/PATIENTS:

All adult patients with ESLD admitted to an urban county teaching hospital over three years with variceal bleeding who received pharmacologic VTEP during hospitalization.

RESULTS:

A total of 22 patients with ESLD and variceal bleeding received pharmacologic VTEP. Only 1 patient rebled after initiation of VTEP; 2 patients were diagnosed with lower extremity deep venous thrombosis while on VTEP including the 1 patient who rebled.

CONCLUSIONS:

VTEP was associated with an unexpectedly low incidence of recurrent bleeding in patients with ESLD and variceal bleeding. Further study may be warranted.

PMID:
20635412
DOI:
10.1002/jhm.777
[Indexed for MEDLINE]
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