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PLoS One. 2010 Jul 9;5(7):e11523. doi: 10.1371/journal.pone.0011523.

Early life disease programming during the preconception and prenatal period: making the link between stressful life events and type-1 diabetes.

Author information

1
Department of Epidemiology, School of Public Health, University of California Los Angeles, Los Angeles, California, United States of America. jasvirk@ucla.edu

Abstract

BACKGROUND:

To assess the risk of developing Type-1 diabetes among children who were exposed to maternal bereavement during the prenatal or 1-year preconception period.

METHODS:

We identified N = 1,548,746 singleton births born in Denmark between January 1(st) 1979 through December 31(st) 2004, and their next of kin. Altogether, 39,857 children were exposed to bereavement during their prenatal life. The main outcome of interest was hospitalization for type-1 diabetes (ICD 8: 249; ICD 10: E10).

RESULTS:

We found the strongest association for type-1 diabetes among children exposed to traumatic father or sibling deaths (aIRR: 2.03, 1.22-3.38); the association was mainly seen for girls (aIRR: 2.91, 1.61-5.26).

CONCLUSIONS:

We found evidence to suggest that female fetuses exposed to severe prenatal stress are at increased risk for developing type-1 diabetes.

PMID:
20634978
PMCID:
PMC2901388
DOI:
10.1371/journal.pone.0011523
[Indexed for MEDLINE]
Free PMC Article

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