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Ultramicroscopy. 1991 Jan;35(1):45-53.

A side-entry cold holder for cryo-electron microscopy.

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Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK.


A side-entry cold holder for cryo-electron microscopy has been constructed which can be used with no loss of image resolution or contrast at 3.4 A resolution compared to the normal room-temperature holder. A description is presented of some of the ideas and tests which we have developed during its construction and are included in the design, together with a briefer outline of the remaining limitations.

[Indexed for MEDLINE]

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