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J Infect Dis. 2010 Sep 1;202(5):690-9. doi: 10.1086/655472.

Human cytomegalovirus induces systemic immune activation characterized by a type 1 cytokine signature.

Author information

1
Renal Transplant Unit, Department of Internal Medicine, Academic Medical Center, Amsterdam, the Netherlands. p.j.vandeberg@amc.nl

Abstract

Mechanisms underlying the onset and perpetuation of chronic immune activation in individuals without overt infectious or autoimmune diseases are unclear. Cytomegalovirus (CMV) is a persistent virus that induces a permanent increase of highly differentiated, interferon-gamma-secreting effector T cells. We hypothesized that, because of this increase, CMV also induces a systemic inflammatory response. We measured acute phase proteins, cytokines, and chemokines in serum samples from renal transplant recipients who developed a primary CMV infection and healthy CMV serum-positive or -negative individuals. Primary CMV infection induced a clear proinflammatory response that was maintained during latency. This response was characterized by increased levels of acute phase proteins, such as serum amyloid-A and C-reactive protein, and type 1 cytokines, such as interleukin-18, interferon-inducible protein-10, and interferon-gamma. This continuous activation of the immune system may play a role in the pathogenesis of chronic allograft rejection and potentially contribute to the acceleration of chronic diseases.

PMID:
20632887
DOI:
10.1086/655472
[Indexed for MEDLINE]

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