Abstract
A bromophenol, bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, was purified from the red alga Polyopes lancifolia. Its IC(50) values were 0.098 and 0.120 microM against Saccharomyces cerevisiae and Bacillus stearothermophilus alpha-glucosidases, respectively, and 1.00 and 1.20 mM against rat-intestinal sucrase and maltase. This bromophenol competitively inhibited S. cerevisiae alpha-glucosidase with a K(I) value of 0.068 microM and was very stable at pH 2 for 60 min at 37 degrees C. Therefore, this P. lancifolia bromophenol may have potential as natural nutraceutical for the management of type 2 diabetes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Catechols / chemistry
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Catechols / isolation & purification
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Catechols / pharmacology*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Ethers / chemistry
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Ethers / isolation & purification
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Ethers / pharmacology*
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Glycoside Hydrolase Inhibitors*
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Phenols / chemistry
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Phenols / isolation & purification
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Phenols / pharmacology*
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Rats
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Rhodophyta / chemistry*
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Rhodophyta / enzymology*
Substances
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Catechols
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Enzyme Inhibitors
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Ethers
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Glycoside Hydrolase Inhibitors
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Phenols
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bis(2,3-dibromo-4,5-dihydroxybenzyl) ether
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2,4-dibromophenol