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Nucleic Acids Res. 1991 Jun 25;19(12):3269-74.

Two hypervariable minisatellite DNA binding proteins.

Author information

1
Department of Genetics, University of Illinois, Chicago 60612.

Abstract

Hypervariable minisatellite DNA sequences are short, tandemly repeated sequences present at numerous loci in eukaryotes. They stimulate intermolecular homologous recombination up to 13-fold in human cells in culture and may be specific sites for the initiation of recombination in the eukaryotic genome (Wahls, W.P., Wallace, L.J., & Moore, P.D. (1990) Cell 60, 95-103). Reported here is the detection and partial purification of two hypervariable minisatellite DNA binding proteins, called Msbp-2 and Msbp-3, present in the nuclear extracts of human HeLa cells. The proteins elute from a gel filtration column with a native mass of 200-250 kDa and have sizes of 77 kDa and 115 kDa respectively.

PMID:
2062643
PMCID:
PMC328321
DOI:
10.1093/nar/19.12.3269
[Indexed for MEDLINE]
Free PMC Article

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