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J Biomed Biotechnol. 2010;2010:740619. doi: 10.1155/2010/740619. Epub 2010 Jun 6.

The IL-2 defect in systemic lupus erythematosus disease has an expansive effect on host immunity.

Author information

1
Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, CLS 937, Boston, MA 02115, USA. llieber1@bidmc.harvard.edu

Abstract

IL-2 production is decreased in systemic lupus erythematosus (SLE) patients and affects T cell function and other aspects of host immunity. Transcription factors regulating IL-2 production behave aberrantly in SLE T cells. In addition to IL-2 dysregulation, other IL-2 family members (IL-15 and IL-21) are abnormally expressed in SLE. Decreased IL-2 production in SLE patients leads to many immune defects such as decreased T(reg) production, decreased activation-induced cell death (AICD), and decreased cytotoxicity. IL-2 deficiency results in systemic dysregulation of host immune responses in patients suffering from SLE disease.

PMID:
20625413
PMCID:
PMC2896881
DOI:
10.1155/2010/740619
[Indexed for MEDLINE]
Free PMC Article

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