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RNA Biol. 2010 Jul-Aug;7(4):403-11. Epub 2010 Jul 1.

Alternative splicing and breast cancer.

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Institut National de la Santé et de la Recherche Médicale (INSERM) U590, Centre Léon Bérard, Lyon, France.


Alternative splicing is a key molecular event in the gene expression process. It allows for the synthesis of different products from the same gene, and consequently increases the complexity of the proteome encoded by a limited number of genes. Although alterations of alternative splicing are among the myriad of alterations present in tumor cells, increasing evidence indicates that cancer-associated splicing variants play an important role in tumor initiation and progression. Therefore, alternative splicing studies are opening new avenues of research in basic and translational molecular oncology.

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