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Biosci Biotechnol Biochem. 2010;74(7):1350-4. Epub 2010 Jul 7.

Evaluation of the protective effects of Chinese herbs against biomolecule damage induced by peroxynitrite.

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1
College of Life Science and Bioengineering, Beijing University of Technology, China. luoyj@bjut.edu.cn

Abstract

This work evaluates the protective effects of Chinese herbs against ONOO(-)-induced biomolecule damage. Thirty-two Chinese traditional herbs were preliminarily screened for their ONOO(-)-scavenging activity by the fluorometric method. The potency of scavenging activity was in the following order: Apis cerana Fabricius (Propolis) > Rosmarinus officinalis L (Rosemary) > Pseudolarix amabilis (Nelson) Rehd. (Pine Bark PE) > Echinacea Moenck. (Echinacea); the remaining twenty-eight herbs performed unsatisfactorily for their scavenging activity. The four extracts with high ONOO(-) scavenging activity were selected for further characterization of their inhibiting effects on DNA single breaks, tyrosine nitration and LDL oxidation. A further study of the origin of this scavenging activity on the major active components showed cichoric acid and rosemary acid to both have strong ability to scavenge ONOO(-). These scavengers might be developed as therapeutic drugs for preventing ONOO(-)-involved diseases.

PMID:
20622443
DOI:
10.1271/bbb.90914
[Indexed for MEDLINE]
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