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HIV-1 Nef binds a subpopulation of MHC-I throughout its trafficking itinerary and down-regulates MHC-I by perturbing both anterograde and retrograde trafficking.

Yi L, Rosales T, Rose JJ, Chowdhury B, Knutson JR, Venkatesan S.

J Biol Chem. 2010 Oct 1;285(40):30884-905. doi: 10.1074/jbc.M110.135947. Erratum in: J Biol Chem. 2010 Dec 3;285(49):38740. Chaudhury, Bhabhadeb [corrected to Chowdhury, Bhabadeb].


Strategies for inhibiting function of HIV-1 accessory proteins: a necessary route to AIDS therapy?

Richter SN, Frasson I, Pal├╣ G.

Curr Med Chem. 2009;16(3):267-86. Review.


HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.

Hung CH, Thomas L, Ruby CE, Atkins KM, Morris NP, Knight ZA, Scholz I, Barklis E, Weinberg AD, Shokat KM, Thomas G.

Cell Host Microbe. 2007 Apr 19;1(2):121-33.


HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes.

Piguet V, Wan L, Borel C, Mangasarian A, Demaurex N, Thomas G, Trono D.

Nat Cell Biol. 2000 Mar;2(3):163-7.

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