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Nutr Metab Cardiovasc Dis. 2011 Oct;21(10):823-9. doi: 10.1016/j.numecd.2010.02.020. Epub 2010 Jun 19.

Meta-analysis on the effect of the Ala54Thr polymorphism of the fatty acid-binding protein 2 gene on body mass index.

Author information

1
Department of Geriatrics, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. zhaotongfeng@yahoo.com.cn

Abstract

BACKGROUND AND AIM:

The results from studies published on the association of fatty acid-binding protein 2 (FABP2) Ala54Thr polymorphism with body mass index (BMI) are conflicting. In this meta-analysis, we investigated the association of the FABP2 Ala54Thr polymorphism with BMI.

METHODS AND RESULTS:

We searched for articles published prior to June 2009 using PubMed, HugeNavigator and China National Knowledge Internet. The languages were limited to English and Chinese. Data on BMI were collected. A pooled weighted mean difference (WMD), together with 95% confidence interval (CI), was used for this meta-analysis. A total of 27 studies with 10 974 subjects were included in this meta-analysis. The pooled effect for dominant, recessive and co-dominant model comparisons did not suggest the significant association between the FABP2 Ala54Thr polymorphism and BMI in overall populations: WMD(fixed effects)=-0.00, 95% CI: (-0.16 to 0.15), p=0.99, WMD(random effects)=-0.00, 95% CI: (-0.16 to 0.15), p=0.99, p(Q)=0.77, I(2)=0%, WMD(fixed effects)=-0.12, 95% CI: (-0.39 to 0.14), p=0.35, WMD(random effects)=-0.12, 95% CI: (-0.39 to 0.14), p=0.35, p(Q)=0.47, I(2)=0% and WMD(fixed effects)=0.07, 95% CI: (-0.11 to 0.25), p=0.45, WMD(random effects)=0.07, 95% CI: (-0.11 to 0.25), p=0.45, p(Q)=0.90, I(2)=0%, respectively. The results from the comparisons of ThrThr versus AlaAla and AlaThr versus AlaAla showed no evidence that the FABP2 Ala54Thr polymorphism is significantly associated with BMI in overall populations (p>0.05). All the results from the subgroup analyses for these genetic models comparisons were not significant (p>0.05).

CONCLUSIONS:

Our meta-analysis does not support the association between the FABP2 Ala54Thr polymorphism and BMI.

PMID:
20621703
DOI:
10.1016/j.numecd.2010.02.020
[Indexed for MEDLINE]

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