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Clin Gastroenterol Hepatol. 2010 Sep;8(9):760-6. doi: 10.1016/j.cgh.2010.05.019. Epub 2010 May 31.

Low incidence of complications from endoscopic gastric variceal obturation with butyl cyanoacrylate.

Author information

1
Department of Gastroenterology and Hepatology, Chinese People's Liberation Army General Hospital, Beijing, China.

Abstract

BACKGROUND & AIMS:

Endoscopic variceal obturation with tissue adhesive is used to control gastric variceal bleeding. We investigated the prevalence of serious complications from this therapy.

METHODS:

We performed a retrospective analysis of complications that occurred in 753 patients with gastric variceal hemorrhages who were hospitalized in 2 tertiary referral hospitals. All patients received N-butyl-2-cyanoacrylate as therapy for endoscopic variceal obturation.

RESULTS:

Complications occurred in 51 patients. Thirty-three patients experienced rebleeding because of early-onset (within 3 months) extrusion of the N-butyl-2-cyanoacrylate glue cast (4.4%), 10 patients developed sepsis (1.3%), and 5 patients developed distant embolisms (0.7%; 1 pulmonary, 1 brain, and 3 splenic). One patient had major gastric variceal bleeding after endoscopic variceal obturation (0.1%), 1 developed a large gastric ulcer (0.1%), and 1 had mesentery hematoma, hemoperitoneum, and infection in the abdominal cavity (0.1%). The complication-related mortality was 0.53% (3 deaths from sepsis and 1 death from rebleeding after early-onset glue cast extrusion).

CONCLUSIONS:

The occurrence of complications after endoscopic variceal obturation with N-butyl-2-cyanoacrylate in gastric varices treatment is rare.

PMID:
20621678
DOI:
10.1016/j.cgh.2010.05.019
[Indexed for MEDLINE]

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