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Autoimmun Rev. 2010 Aug;9(10):691-4. doi: 10.1016/j.autrev.2010.05.020. Epub 2010 Jun 4.

Anti-Ku antibodies: Clinical, genetic and diagnostic insights.

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  • 1Internal Medicine Department, University Hospital Angers, France.


Anti-Ku antibodies are reported in various connective tissue diseases and the Ku complex can be responsible for a very strong autoimmune answer in autoimmune disease. Nowadays, anti-Ku antibodies are detected by ELISA, counterimmunoelectrophoresis (CIE), immunoblot (IB) and new highly performant techniques. Although the prevalence of anti-Ku antibodies is not homogenous, depending on several features such as disease type, genetic and geographical clustering, and also method of detection, they could be found in 55% overlap PM/systemic sclerosis patients. Moreover, anti-Ku antibodies are not associated with a particular clinical outcome, and especially with cancer related to myositis.

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